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NICE technology appraisal

for Hybrid Closed Loop systems

NICE now recommends Hybrid Closed Loop (HCL) systems for selected people with type 1 diabetes2

Biker with sensor looking at her phone
Biker with sensor looking at her phone
Biker with sensor looking at her phone

The new NICE technology appraisal recommendation means more people with type 1 diabetes qualify for a Hybrid Closed (HCL) compatible real-time CGM system


NICE guidelines for HCL

NICE recommends HCL2 as an option for managing blood glucose levels in type 1 diabetes in:3

  • Adults with HbA1c ≥7.5% (58mmol/mol), or who have disabling hypoglycaemic episodes despite continuous subcutaneous insulin (CSII), real-time continuous glucose monitoring (rtCGM) or intermittently scanned CGM (isCGM)

  • Children and young people

  • Those who are pregnant or are planning pregnancy

HCP with Hybrid Closed Loop system

Benefits of HCL systems2,8

Improved HbA1c

Increased Time in Range

Reduced hypoglycemia

Reduced diabetes distress

Improved quality of life

FreeStyle Libre 3 sensor: An HCL-compatible CGM system

FreeStyle Libre 3 sensor with mylife Loop1

Available now

The most accurate 14-day CGM system4,5 delivering minute-to-minute glucose readings from the world’s smallest sensor,6 connected with mylife Loop for automated insulin delivery that runs from a compatible smartphone7 and the mylife YpsoPump insulin pump for automated insulin delivery.

FreeStyle Libre 3 and Ypsomed

The FreeStyle Libre 3 system

NextGen CGM performance you and your Healthcare Professional can count on

The FreeStyle Libre 3 system is the most accurate4,5 and reliable9,10 14-day CGM with an overall MARD of 7.8%.

The system is authorised to work with the mylife Loop AID system1 for easier diabetes management and improved glycaemic control.

FreeStyle Libre 3 and Ypsomed

References & Disclaimers

Images are for illustrative purposes only. Not real patient or data. mylife and YpsoPump are registered trademarks of Ypsomed Group.

1. FreeStyle Libre 3 is authorised to work with the mylife Loop automated insulin delivery system, including the mylife CamAPS FX app and mylife YpsoPump insulin pump. For use of FreeStyle Libre 3 sensor with the mylife Loop, refer to the labeling provided with the mylife CamAPS FX app.

2. NICE [2023] Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes. [GID-TA10845]. Visit

3. Only use hybrid closed loop systems with the support of a trained multidisciplinary team experienced in continuous subcutaneous insulin infusion and continuous glucose monitoring in type 1 diabetes. Only use hybrid closed loop systems if the person or their carer understands and is able to use them, and is also attending a type 1 diabetes structured education programme. 

4. Comparison based on publicly available information. Data on fi le, Abbott Diabetes Care Inc.

5. FreeStyle Libre 3 User’s Manual. FreeStyle Libre 3 demonstrates 7.8% overall MARD with 7.5% adult MARD and 8.6% pediatric MARD (age 6-17) in accuracy to YSI.

6. Among patient-applied sensors.

7. Note that patients require a compatible mylife YpsoPump to use the mylife CamAPS FX app for automated insulin delivery and the mylife App with remote bolus feature.

8. Crabtree TSJ, Griffin TP, Yap YW, Narendran P, Gallen G, Furlong N, Cranston I, Chakera A, Philbey C, Karamat MA, Saraf S, Kamaruddin S, Gurnell E, Chapman A, Hussain S, Elliott J, Leelarathna L, Ryder REJ, Hammond P, Lumb A, Choudhary P, Wilmot EG; ABCD Closed-Loop Audit Contributors. Hybrid Closed-Loop Therapy in Adults With Type 1 Diabetes and Above-Target HbA1c: A Real-world Observational Study. Diabetes Care. 2023 Oct 1;46(10):1831-1838. doi: 10.2337/dc23-0635. PMID: 37566697; PMCID: PMC10516256.

9. CGM reliability defined by signal connection. Data on file, Abbott Diabetes Care, Inc.

10. Comparison based on Dexcom G6 CGM User Guide, Dexcom G7 CGM User Guide, and Medtronic Guardian Connect System User Guide.