1. Data on file, Abbott Diabetes Care, Inc. Based on the number of users worldwide for the Libre portfolio compared to the number of users for other leading personal use sensor-based glucose monitoring systems.
2. Data on file, Abbott Diabetes Care, Inc.
3. Hilliard, M., et al. Diabetes Technology & Therapeutics. (2019). https:/doi.org/10.1089/dia.2019.0142.
4. Haak, T. Diabetes Therapy (2017). https://doi.org/10.1007/s13300-016-0223-6.
5. Alva, S. J Diabetes Sci Technol (2020): https://doi.org/10.1177%2F1932296820958754.
6. The views, opinions, and positions expressed by FreeStyle Libre systems users are theirs alone, and do not necessarily reflect the views, opinions, and positions of Abbott or any employee thereof.
7. Fokkert, M. BMJ Open Diabetes Research & Care (2019). https://doi.org/10.1136/bmjdrc-2019-000809.
8. 60-minute warm-up required when applying the sensor.
9. Sensor is water resistant in up to 1 meter (3 feet) of water. Do not immerse longer than 30 minutes.
10. Finger pricks are required if glucose alarms and readings do not match symptoms or when you see Check Blood Glucose symbol during the first twelve hours.
11. Among patient-applied sensors.
14. FreeStyle Libre, FreeStyle Libre 2 systems are part of the same family of products.
15. Based on the reading frequency in Dexcom G6 CGM User Guide and Medtronic Guardian Connect System User Guide compared to readings every minute for FreeStyle Libre 2 systems sensors.
16. Huang, E. Diabetes (2022). https://doi.org/10.2337/db22-73-LB.
17. Unger, J. Postgraduate Medicine (2020). https://doi.org/10.1080/00325481.2020.1744393.
18. Notifications will only be received when alarms are enabled and turned on and the sensor is within 20 feet / 6 meters (FreeStyle Libre 2 system) unobstructed of the reading device.
20. Campbell, F. M. Pediatric Diabetes (2018). https://doi.org/10.1111/pedi.12735.
23. Data on file, Abbott Diabetes Care, Inc. Based on the signal strength in Dexcom G6 CGM User Guide and Medtronic Guardian Connect System User Guide.
27. Evans, M. Diabetes Therapy (2022). https://doi.org/10.1007/s13300-022-01253-9.
28. Bolinder, J. The Lancet (2016). https://doi.org/10.1016/S0140-6736(16)31535-5.
29. Only new users of FreeStyle Libre are eligible to participate in the FreeStyle Libre Experience Program. Existing or past users of FreeStyle Libre products are not eligible to join the Program. Abbott reserves the right to verify the eligibility of participants of this Program. Each eligible participant can purchase 1 FreeStyle Libre starter kit that contains 1 reader and 1 sensor, for RM310. As part of the Experience Program, participants will receive SMS notifications for appointment confirmations and reminders the day before the event. As part of the Experience Program, participants will also receive emails and SMS to support their journey as new users of FreeStyle Libre. These emails will include educational and promotional content. After the Experience Program, users will continue to receive marketing content via emails and SMS. You can opt out of these communications at any time via the unsubscribe link in emails, or you may contact us at ADC-CS.MY@abbott.com or through our hotline at 1800-88-2328 to update your consent. To the extent permissible by law, Abbott shall not be responsible for any loss or damage sustained by a participant while participating in the Program, unless such loss or damage is proven to be solely and directly caused by Abbott. Abbott reserves the right to vary these terms and conditions at any time without prior notice and at its sole discretion.
30. FreeStyle Libre 2 User's Manual/Data on file, Abbott Diabetes Care. Inc.
32. Cengiz, Eda, and William V Tamborlane. “A Tale of Two Compartments: Interstitial Versus Blood Glucose Monitoring.” Diabetes Technology & Therapeutics 11, Suppl 1 (June 2009): S11-6. https://doi.org/10.1089/dia.2009.0002.
38. Yaron, M. Diabetes Care (2019): https://doi.org/10.2337/dc18-0166.
39. Leelarathna, L. New England Journal of Medicine (2022). https://doi.org/10.1056/nejmoa2205650.
40. Leading manufacturers include Accu-Chek, OneTouch and Ascencia.
43. For in-vitro diagnostic use only.
201. National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Diet, Eating, & Physical Activity. 2016. Accessed 25 Aug 2022. Available at: https://www.niddk.nih.gov/health-information/diabetes/overview/diet-eating-physical-activity.
202. Centers for Disease Control and Prevention. Monitoring Your Blood Sugar. Accessed 15 May 2024. Available at: https://www.cdc.gov/diabetes/diabetes-testing/monitoring-blood-sugar.html
203. American Diabetes Association. Better blood glucose meters and more. Accessed 20 May 2023. Available at: https://diabetes.org/tools-support/devices-technology.
204. Ajjan R, et al. Continuous Glucose Monitoring: A Brief Review for Primary Care Practitioners. Adv Ther 2019;36:579-596. https://doi.org/10.1007/s12325-019-0870-x.
205. Vincze G, et al. Factors Associated With Adherence to Self-Monitoring of Blood Glucose Among Persons With Diabetes. Diabetes Educ 2004;30(1):112-125. doi:10.1177/014572170403000119.
206. Wagner J, et al. Invasiveness as a barrier to self-monitoring of blood glucose in diabetes. Diabetes Technol Ther. 2005 Aug;7(4):612-9. doi: 10.1089/dia.2005.7.612.
207. Foster NC, et al. State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018. Diabetes Technol Ther 2019;21(2):66-72. https://doi.org/10.1089/dia.2018.0384.
208. Brixner D, et al. Clinical and Economic Outcomes of Patients with Type 2 Diabetes on Multiple Daily Injections of Basal-bolus Insulin (MDI) Therapy: A Retrospective Cohort Study. Clinical Therapeutics 2019;41(2):303-313. doi: 10.1016/j.clinthera.2018.12.014.
209. Scanning the sensor to obtain glucose values does not require lancets. To get a 24-hour glycaemic picture, users need to scan at least once every 8 hours
210. Battelino T, et al. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range. Diabetes Care. 2019. https://doi.org/10.2337/dci19-0028.
211. American Diabetes Association. Standards of medical care in diabetes—2020. Diabetes Care. 2020;43(1):S77-S88.
212. Vigersky RA, et al. The Relationship of Hemoglobin A1C to Time-in-Range in Patients with Diabetes. Diabetes Technol Ther. 2019 Feb;21(2):81-85. doi: 10.1089/dia.2018.0310.
213. Nuha A. ElSayed, et al. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2023. Diabetes Care. Jan 2023; 46 (Supplement_1): S68–S96.
214. Very Well Health. Understanding Nocturnal Hypoglycemia.
215. Joseph JJ, Golden SH. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017 Mar;1391(1):20-34.
216. Wright E, et al. Diabetes Spectrum. 2021;34(2):184–189
217. Charleer S, et al. Diabetes Care 2020;43(2):389-397
218. Hirst JA, et al. Diabetes Care. 2012;35(2):446–454.
219. Miller E, Brandner L, Wright E. HbA1c reduction after initiation of the FreeStyle Libre system in type 2 diabetes patients on long-acting insulin or non-insulin therapy [84-LB]. Poster presented at: 80th Scientific Sessions of the American Diabetes Association; June 12-16, 2020;Virtual.
220. Results from the SELFY Study for diabetes self-management with children (4-12 years) and teenagers (13-17 years), children aged 4-12, a caregiver at least 18 years old is responsible for supervising, managing, and assisting them in using the FreeStyle Libre system and interpreting its readings.
221. Data from this study was collected with the outside US version of FreeStyle Libre 14 day system. FreeStyle Libre 2 system has the same features as FreeStyle Libre 14 day system with optional, real-time glucose alarms. Therefore, the study data is applicable to both products.
222. Scott EM, et al. Diabetes Technol Ther 2018;20(3):180-188.
223. Bailey T, et al. The Performance and Usability of a Factory-Calibrated Flash Glucose Monitoring System. Diabetes Technology & Therapeutics. 2015;17(11):787-794
224. National Institute of Diabetes and Digestive and Kidney Diseases. Type 2 Diabetes. Accessed 3 July 2023. Available at: https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/type-2-diabetes.
225. Speak to your clinician before making changes to your diabetes management plan.
226. Ministry of Health Malaysia. Diabetic Meal Plan. 2013. Accessed 18 April 2023. Available at: http://pendidikanpesakit.myhealth.gov.my/en/diabetic-meal-plan/.
227. The meter logbook can store up to 1,000 events including blood glucose, ketone, and control solution results, insulin doses, and other meter information.
228. Optium Neo BGM User's manual insert
229. WebMD Editorial Contributors. (2024, January 18). Hypoglycemia (Low blood sugar). WebMD. https://www.webmd.com/diabetes/diabetes-hypoglycemia
230. Mayo Clinic. (2024, January 16). Blood sugar testing: Why, when and how. https://www.mayoclinic.org/diseases-conditions/diabetes/in-depth/blood-sugar/art-20046628#:~:text=Your%20healthcare%20professional%20may%20suggest,after%20and%20sometimes%20during%20exercise
231. A finger prick test using a blood glucose meter is required during times of rapidly changing glucose levels when interstitial fluid glucose levels may not accurately reflect blood glucose levels or if hypoglycaemia or impending hypoglycaemia is reported by the system or when symptoms do not match the system readings.
232. Based on the Sensor being replaced once every 15 days and scanned at least once every 8 hours.
233. Hortensius, Johanna., et al. Perspectives of patients with type 1 or insulin-treated type 2 diabetes on self-monitoring of blood glucose: a qualitative study. BMC Public Health 12.1 (2012):167.
234. Acetaminophen Interference on ISF Based Glucose Monitoring Systems Alva, S., Chen, T., Naegeli, A. poster presented at DTT 2017.
235. Rebrin K, Steil GM. Can interstitial glucose assessment replace blood glucose measurements? Diabetes Technol Ther. 2000;2(3):461-472.
236. Rebrin K, Sheppard NF Jr, Steil GM. Use of subcutaneous interstitial fluid glucose to estimate blood glucose: revisiting delay and Sensor offset. J Diabetes Sci Technol. 2010;4(5):1087-1098.
237. Data on File, Abbott Diabetes Care Inc, Clinical Report: Evaluation of the Accuracy of the Abbott Sensor-Based Interstitial Glucose Monitoring System 2014.
238. Nathan DM, Kuenen J, Borg R, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31:1473-1478.
239. Hirsch I and Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control? Journal of Diabetes and its Complications, 2005:19:178-181
240. Kohnert K. Vogt L. Salzsieder E. Advances in understanding glucose variability and the role of continuous glucose monitoring. Eur Endocrinol. 2010: 6:53-56.
241. Bergenstal RM, Ahmann AJ, Bailey T, et al. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the ambulatory glucose profile (AGP). Diabetes Technol & Ther. 2013;15(3):198-211
242. FS Optium Neo Product Strip Insert
243. Study data was collected with US FreeStyle Libre 2 system and is applicable to the FreeStyle Libre and FreeStyle Libre 3 system based on technological similarities.
244. Lee WC, et al. Frequency of blood glucose testing among insulin-treated diabetes mellitus patients in the United Kingdom. J Med Econ. 2014 Mar;17(3):167-75. doi: 10.3111/13696998.2013.873722.
300. Default range is 70-180 mg/dL. Consult with a healthcare professional on individual target glucose range.
301. Results of meals and exercise may vary. Be sure to talk to your healthcare team about what is best for you.
302. American Diabetes Association. “UNDERSTANDING A1C: What Is the A1C Test?” Accessed 7-30-24. https://diabetes.org/about-diabetes/a1c
303. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2019 Oct 15]. Human Insulin Injection; [updated 2019 Oct 15; cited 2024, July 30]; [about 5 p.]. Available from: https://medlineplus.gov/druginfo/meds/a682611.html
304. Patel, Dhara, et al. “The Effectiveness of Metformin in Diabetes Prevention: A Systematic Review and Meta-Analysis.” Cureus. 2023 Sep; 15(9): e46108. Published online 2023 Sep 28. doi: 10.7759/cureus.46108
305. Battelino, T. “Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.” Diabetes Care (2019) 42(8):1593–1603: https://doi.org/10.2337/dci19-0028
306. Beck, Roy W., Richard M. Bergenstal, Peiyao Cheng, Craig Kollman, Anders L. Carlson, Mary L. Johnson, and David Rodbard. “The relationships between time in range, hyperglycemia metrics, and HbA1c.” Journal of Diabetes Science and Technology 13, no. 4 (2019): 614-626. https://doi.org/10.1177/1932296818822496
307. Mayo Clinic. “Blood sugar levels can fluctuate for many reasons.” Accessed 7-30-24. https://www.mayoclinic.org/diseases-conditions/diabetes/expert-answers/glucose-levels/faq-20424316
308. American Diabetes Association. “Blood Glucose and Insulin.” Accessed 7-30-24. https://diabetes.org/about-diabetes/high-blood-sugar
309. American Diabetes Association. Diabetes Care 2024;47(Supplement_1):S77–S110 https://doi.org/10.2337/dc24-S005
310. American Diabetes Association. “Exercise & Type 1.” Accessed 7-30-24. https://diabetes.org/health-wellness/fitness/exercise-and-type-1
311. Individual responses to meals, medication, and exercise may vary.
312. The National Health Service, UK. “Food and keeping active.” Accessed 7-31-24. https://www.nhs.uk/conditions/type-2-diabetes/food-and-keeping-active/
313. The British Diabetic Association operating as Diabetes UK. “I have type 2 diabetes – what can I eat?” Accessed 7-31-24. https://www.diabetes.org.uk/guide-to-diabetes/enjoy-food/eating-with-diabetes/i-have-type-2-diabetes
314. American Medical Association. “Foods that spike a patient’s blood glucose are not what you think.” Accessed 7-31-24. https://www.ama-assn.org/delivering-care/diabetes/foods-spike-patient-s-blood-glucose-are-not-what-you-think
315. American Diabetes Association. “Diabetes Superstar Foods: Taking Charge of Your Health Through Food” Accessed 7-31-24. https://diabetes.org/food-nutrition/food-and-blood-sugar/diabetes-superstar-foods
316. American Diabetes Association. “Know Your Facts About Diabetes.” Accessed 7-31-24. https://diabetes.org/about-diabetes/diabetes-myths
317. Harvard Health Publishing, Harvard Medical School. “The truth about fats: the good, the bad, and the in-between.” Accessed 7-31-24. https://www.health.harvard.edu/staying-healthy/the-truth-about-fats-bad-and-good
318. Mayo Clinic. “Dietary fiber: Essential for a healthy diet.” Accessed 7-31-24. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/fiber/art-20043983
319. U.S. Department of Agriculture. “Pasta, cooked, unenriched, without added salt.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/168928/nutrients
320. U.S. Department of Agriculture. “Eggplant, cooked, no added fat.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/2345452/nutrients
321. U.S. Department of Agriculture. “Potatoes, white, flesh and skin, raw.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/170028/nutrients
322. U.S. Department of Agriculture. “Kohlrabi, raw.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/168424/nutrients
323. U.S. Department of Agriculture. “Tortilla, flour.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/2343304/nutrients
324. U.S. Department of Agriculture. “Tortilla, corn.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/2343303/nutrients
325. U.S. Department of Agriculture. “Potato, french fries, from fresh, fried.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1102958/nutrients
326. U.S. Department of Agriculture. “Squash, summer, zucchini, includes skin, raw.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food
327. U.S. Department of Agriculture. “Wheat flour, white, cake, enriched.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/169723/nutrients
328. U.S. Department of Agriculture. “Black beans, from canned, no added fat.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/2342838/nutrients
329. U.S. Department of Agriculture. “Wheat flour, white, all-purpose, unenriched.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/169761/nutrients
330. U.S. Department of Agriculture. “Chickpeas (garbanzo beans, Bengal gram), mature seeds, canned, drained solids.” Accessed 7-31-24. https://fdc.nal.usda.gov/fdc-app.html#/food-details/173800/nutrients
331. Talk to your healthcare professional to make sure your [exercise/activity] program is safe for you.
332. Do not ignore symptoms that may be due to low or high blood glucose: If you are experiencing symptoms that are not consistent with your glucose readings, consult your health care professional.
333. American Diabetes Association. “Blood Glucose and Exercise.” Accessed 7-31-24. https://diabetes.org/health-wellness/fitness/blood-glucose-and-exercise
334. Centers for Disease Control and Prevention. “Get Active.” Accessed 7-31-24. https://cdc.gov/diabetes/living-with/physical-activity.html
335. American Diabetes Association. “Fitness. It’s a great time to get moving.” Accessed 7-31-24. https://diabetes.org/health-wellness/fitness
336. Based on the number of users worldwide for the Libre portfolio compared to the number of users for other leading personal-use sensor-based glucose monitoring systems.
ADC-92365 v1.0