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ISF is a reasonable alternative for blood. Glucose can be measured in the ISF–the fluid around the body’s cells where glucose freely diffuses from capillaries to the interstitial space.²⁰⁷ The physiological delay in ISF glucose with respect to changes in blood glucose is about 5-10 minutes²⁰⁸ which is unlikely to impact routine day-to-day treatment decisions. The average lag time of the FreeStyle Libre system is approximately 5 minutes.²⁰⁹