What rising ketones and DKA mean when living with diabetes496

mother stroking the head of sick child lying down.

Gibran was playing soccer as a child when he was rushed to the hospital with his first diabetic ketoacidosis (DKA) episode.

Photo of Gibran, who was diagnosed with Type 1 diabetes after a DKA episode.

“I was going to the restroom every five minutes, feeling nauseous, dehydrated, and my breath was smelling funky,” he recalls. By the time his parents took him to the hospital, he had lost 20 pounds in two weeks—and he was minutes away from going into a coma. This is how Gibran, now a youth soccer coach, was first diagnosed with Type 1 diabetes495,6

It’s not unusual for people with diabetes to mistake the symptoms of high ketones or DKA for an illness like the flu519. But the symptoms could be something more serious: diabetic ketoacidosis (DKA), a condition that can impact anyone who relies on insulin504 or SGLT2 inhibitors520.

For people living with diabetes, DKA is actually the most common emergency related to high glucose levels497,499, though in rare cases DKA can actually happen without high glucose497,510.

Don’t know much about DKA?

You’re not alone498,567.

46%

Many people living with diabetes are unable to name DKA symptoms498,567.

If you think you might have DKA, seek medical care right away496.

Keep reading to learn about diabetic ketoacidosis:

  • What is DKA and what causes it? 
  • What DKA feels like & DKA symptoms
  • How to prevent DKA

What is diabetic ketoacidosis (DKA)?

Caregiver holding child in her arms.

Ketones can build up if the body doesn’t have enough insulin496.

  1. Without insulin, cells can’t use glucose for energy496. Glucose then starts building up in the blood478.
  2. The body still needs fuel, so it may start breaking down fat to use instead of glucose481
  3. Breaking down fat results in acidic chemicals called ketones, which can accumulate in the blood481.

A small amount of ketones is normal503—typically under 0.6mmol/L504. Be sure to talk to your healthcare professional to establish a safe action plan if ketones go above 0.6 mmol/L.

When too many ketones collect in your bloodstream, they can make your blood dangerously acidic. If not treated, ketone buildup can progress to DKA, which is a life-threatening condition481 that cannot be treated at home—DKA requires emergency medical care505.

What causes DKA?

DKA is caused by not having enough insulin in your body. Some situations, such as stress or illness, can cause your body to need more insulin than usual—increasing the risk of DKA505.

Person suffering symptoms of DKA laying in bed.

Common DKA triggers include505:

  • Missing one or more insulin doses
  • Using expired or spoiled insulin
  • Illness or infections
  • Dehydration, as from vomiting  
  • Severe physical or emotional stress
  • Alcohol use
  • Certain medications like SGLT2 inhibitors

What DKA feels like—and how to recognize DKA symptoms.

Ketones may rise slowly at first506 but can escalate to an emergency in just a few hours497,506,516.

Early DKA symptoms include505

  • Excessive thirst 
  • Intense hunger
  • Frequent urination
  • Dehydration

More severe DKA symptoms include505:

  • Nausea and vomiting
  • Abdominal pain
  • Fruity-smelling breath, caused by ketones
  • Rapid, deep breathing
  • Confusion
  • Fatigue or weakness
  • Loss of consciousness

Diabetes management tips for preventing DKA.

If you have diabetes, the following tips can help you stay ahead of elevated ketones and avoid an emergency505:

  • Take your insulin or other diabetes medication as your healthcare provider instructs.
  • Check your insulin pump for issues or disconnections that could prevent you from receiving insulin.
  • Talk to your doctor about what to do if you get sick, as illness can trigger DKA.

You’re not alone in your diabetes management. Talk to your healthcare provider505 for help making a plan and learning when to take action.

Diabetic ketoacidosis: Your frequently asked questions.

Hyperglycemia happens when you have too much glucose in your bloodstream477. With DKA, you might have high glucose levels, or levels could be lower than 11.1 mmol/L497.

DKA is defined by dangerously high ketones that make the blood too acidic. When your body doesn’t have enough insulin to use glucose for energy, it starts breaking down fat instead. This produces ketones that can build up quickly and become dangerous500.

A DKA diagnosis typically includes glucose levels of 13.9 mmol/L or more. But DKA can happen even if your glucose isn’t high. This is called euglycemic DKA, and is rarer than typical DKA497.

Yes, people living with Type 2 diabetes can experience DKA, although it’s more common among people living with Type 1 diabetes505. If you live with Type 2 diabetes, taking SGLT2 inhibitors may increase your risk of DKA, but your risk remains relatively low520.

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