Why is the Ambulatory Glucose Profile (AGP) an important tool when assessing glucose?

AGP is a visual snapshot of a patient’s typical day using dense glucose data revealing hypoglycaemic and hyperglycaemic trends behind A1c results to facilitate better patient therapy and interaction. Glucose variability in addition to A1c result may be a more reliable indicator of glycemic control than A1c alone.¹ AGP goes beyond A1c by revealing hypoglycaemia, hyperglycaemia and glucose variability.  The most important identified aspect of AGP is that it reveals glucose variability, post-prandial glucose excursions and hypoglycemic trends.² High glucose variability can lead to increased risk for hypoglycaemia.  This is because efforts to control the highs can result in dangerous lows at the other side of the range.³'⁴  AGP reveals glucose variability by 2 measures.  The distance between the 5th and 95th percentile curves shows how widely glucose readings have varied at that time of the day.  A median curve that rises and falls shows glucose instability across the day. 

1Hirsch I and Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control? Journal of Diabetes and its Complications, 2005:19:178-181.  2Kohnert K. Vogt L. Salzsieder E. Advances in understanding glucose variability and the role of continuous glucose monitoring. Eur Endocrinol. 2010: 6:53-56. 3 Bergenstal RM, Ahmann AJ, Bailey T, et al. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the ambulatory glucose profile (AGP). Diabetes Technol & Ther. 2013;15(3):198-211. 4Data on file. Abbott Laboratories Limited.

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